The Role of Alpha–1 Antitrypsin in Emphysema
نویسندگان
چکیده
Alpha-1 antitrypsin (AT) is a member of the serine proteinase inhibitor (SERPIN) superfamily. It is an acute phase protein produced constitutively, primarily by hepatocytes, and is secreted in to the plasma from where it diffuses into the lung. AT is the most abundant proteinase inhibitor within the lung whose main physiological role is to regulate neutrophil elastase (NE) liberated from activated neutrophils (Brantly et al., 1988a; Lomas and Mahadeva, 2002).
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